Zhao Junning, Wang Xiaodong, Peng Longling, et al. Effects of Jiawei Shipiyin Decoction(JS)on Adriamycin-induced Nephrotic Syndrome in Rats[J]. Chinese journal of experimental traditional medical formulae, 1996, 2(6): 12-15.
Zhao Junning, Wang Xiaodong, Peng Longling, et al. Effects of Jiawei Shipiyin Decoction(JS)on Adriamycin-induced Nephrotic Syndrome in Rats[J]. Chinese journal of experimental traditional medical formulae, 1996, 2(6): 12-15.DOI:
An experimental nephrotic syndronie in rats was estabilished by a single intravenous injection of adriamycin 7.5mg/kg
It was characterized by heavy albuminuria
hypoproteinemia
swelling of glomerulus
lesion of glomerular polyanion and high concentration of LPO in kidnev tissue. JS at a dose of 5 or 10g/kg po daily could attenuate these pathological changes significantly.