Effect and Mechanism of Active Fraction A from Guizhi Decoction on Dual-Directional Thermoregulation——Effect on AVP in Hypothalamus and Ventral Septal Area and NT in Hypothalamus in Rats
Huo Hairu, Tan Yuqing, Li Xiaoqin, et al. Effect and Mechanism of Active Fraction A from Guizhi Decoction on Dual-Directional Thermoregulation——Effect on AVP in Hypothalamus and Ventral Septal Area and NT in Hypothalamus in Rats[J]. Chinese journal of experimental traditional medical formulae, 1999, 5(1): 33-36.
Huo Hairu, Tan Yuqing, Li Xiaoqin, et al. Effect and Mechanism of Active Fraction A from Guizhi Decoction on Dual-Directional Thermoregulation——Effect on AVP in Hypothalamus and Ventral Septal Area and NT in Hypothalamus in Rats[J]. Chinese journal of experimental traditional medical formulae, 1999, 5(1): 33-36.DOI:
might lower febrifacient temperature induced by y east in febrile rat with decreasing contents of arginine vasopressin (AVP) in ventral septal area(VSA) and neurotensin(NT)in hypothalamus.Fr.A did not influence the content of AVP in hypothalamus.In aminopyrine-induced hypothermal rats
Fr.A could raise body temperature and contents of AVP in both hypothalamus and VSA and NT in hypothalamus.The results indicated that febrifugal effect of Fr.A was related with its promoting release of AVP in VSA and NT in hypothalamus
while its inhibiting release and/or action of AVP and NT in the thermoregulatory center was involved in mechanism of Fr. A ragulating hypothermia.