Objective: To investigate the effect of Guanmaitong capsule (GMT) on hemodynamic in Beagle dogs. Method: Forty-two Beagle dogs were randomly divided into seven groups: the sham operated control group

model group

GMT groups(0.20

0.40

0.80 g·kg-1)

Guanxin Danshen capsules group(0.07g·kg-1)

isosorbide dinitrate tablets group (0.80×10-3g·kg-1).The Beagle dogs were administered by ig for six days. At the seventh day

acute myocardial ischemic model dogs were established by ligating left anterior decending coronary artery(LAD).Guanmaitong capsule was administered to the canine by duodenal enema. Some hemodynamic parameters were observed. Result: Compared with the sham operated control group

the model group of left ventricular end dilated pressure (LVEDP) was decreasing (P<0.05

P<0.01) and left ventricular systolic pressure(LVSP). ±dp/dtmax and cardiac output(CO) was raising obviously (P<0.05

P<0.01).At the points of 90

120

180 min

the low

medium and high dose of Guanmaitong capsule could decrease LVEDP (all P<0.05)

but raise LVSP

±dp/dtmax

CO(all P<0.05) after ligation of LAD. Conclusion: It indicates Guanmaitong capsule can improve the hemodynamic conditions of myocardial ischemic dogs.