Objective:To observe the therapeutic effects of Polyrhachis vicina Roger on gout. Method: Kunming mice and Wistar rats were randomly divided into control group

model group

positive control group

P. vicina low

medium and high dose groups(1

2

4 g·kg-1)

respectively. The anti-gout effects of P. vicina were studied by observing its effects on the level of blood uric acid in hyperuricacidemia mice induced by hypoxanthine and nomal mice

and rat’s foot swelling induced by microcrystalline sodium urate (MSU) after 15 days treatment. Result: Compared to the level of blood uric acid in control group(131.09±45.78) μmol·L-1and model group(198.63±47.27)μmol·L-1

medium(2 g·kg-1) and high dose groups(4 g·kg-1)of P. vicina alcohol extract

and high dose group(4 g·kg-1)water extract could reduce the blood uric acid in model mice

and satisfactory inhibited acute gouty arthritis

relieved rat’s foot welling in model rats induced by MSU in 3 hours.The effects of P. vicina alcohol extract on gout was better than that in water extract. Conclusion: P. vicina could inhibit the level of blood uric acid in hyperuricacidemia mice induced by hypoxanthine and inflammation induced by MSU

which indicates that P. vicina has therapeutic effect on gout.