Objective:To study the effect of Qishen Jiangu granula(QSJGG) on lipid metabolism of avascular necrosis of the femoral head induced by hormone combining endotoxin. Method: Sixty SD rats were divided into 6 groups

respectively the control group

the model group

the low

medium

high-dose group(15

30

60 g·kg-1) of QSJGG

and the positive control group(3 g·kg-1)

and each group was replicated. Avascular necrosis of femoral head(ANFH) experimental animal model was made by muscle injection of methylprednisolone(20 mg·kg-1) for 3 days after injection of IOCV lipopolysaccharide(20 μg·kg-1) for 2 days in addition of the control group

after 8 week intragastric pre-administration of the medication

rats were sacrificedto collect blood from abdominal vein to determination of serum cholesterol(TC)

triglyceride(TG)

high density lipoprotein (HDL-C) and low density lipoprotein(LDL-C)

and femurs were obtained from both sides

of which the right side was used for pathological sections of HE staining to make observation of bone tissue. Result: To Compared with the model normal rats

fat cells of medullary cavity in the QSJGG group was more and relativity big(P<0.01)

TC

TG and LDL-C leels were increased(P<0.01

P<0.05)

HDL-C was reduced(P<0.05). Compared with group

fat cells of medullary cavity in the model group was less and relativity small

TC

TG and LDL-C were reduced

HDL-C was increased. Conclusion: QSJGG can significantly improve fat metabolism of model of femoral head necrosis

which control femoral head necrosis.