Objective:To observe the amelioration of Naoerkang and its splited prescription on the expression of brain-derived neurotrophic factor(BDNF) in cortex and hippocampus of senile dementia mice model. Method: Seventy male Kunming mice were randomly divided into 7 groups with 10 for each group

then ip AlCl3 solution 100 mg·kg-1

ip

q.o.d for 40 days to induce the model. After the examination of their ability in learning and memory

each mouse of the control group and model group had been forced to drink saline solution(0.5 mL·d-1)

the other groups had been forced to drink the response medicine(14.3 g·kg-1·d-1)every day for 30 days. The positive expression of BDNF in right cortex

hippocampus

and the dentate gyrus of the mice in each group were examined. Result: ①Compared with the model group

the expression of BDNF was increased evidently(P <0.01)in the mice of Naoerkang group and splited prescription 1 group

while the expression of different levels increased only in other groups (P<0.05). ②All of its decomposed recipes compared with the Naoerkang group

there were no significant differences existed in splited prescription 1 and Naoerkang group. ③Compared with the splited prescription 1

there were no significant differences existed neither in dentate gyrus and cortex of splited prescription 2

nor in dentate gyrus of splited prescription 3 and 4. Conclusion: Decomposed recipe 1 and Naoerkang groups have a better effect of promoting the expression of BDNF in brains of AD mice model than any other splited prescription.