Objective:To investigate the anti-inflammatory effect of total flavones of Trollius chinensis Bge (TFTL). Method: The experiments of carrageenin-induced paw edema in rats

histamine-induced pigment oozing from skin vessel in rats and cotton pellet granuloma in rats were used to investigate the effect of TFTL (0.1

0.2

0.4 g·kg-1) on acute and chronic inflammation. Aspirin (Asp) and Jinlianhua tablets (JLHT) were used as positive controls. Result: In 0.2

0.4 g·kg-1 of TFTL groups

the intradermal area of pigment infiltration and pigment content in rats

the paw edema degree in rats and the weight of cotton pellet granuloma in rats were lower than those in the model groups(P<0.05

P<0.01). In 0.4 g·kg-1 of TFTL group

the intradermal pigment content in rats

the paw edema degree of rats and the weight of cotton pellet granuloma in rats were lower than those in JLHT 2.4 g·kg-1 group(P<0.05). In 0.4 g·kg-1 of TFTL group

the paw edema degree was lower than that of Asp 200 mg·kg-1 group(P<0.05). In the test of c arrageenin-induced paw edema in rats

the duration of anti-inflammatory effect in 0.2 g·kg-1 and 0.4 g·kg-1 of TFTL groups were 5-6 h

while the duration of anti-inflammatory effect in 0.2 g·kg-1 of Asp group were 3 h. Conclusion: TFTL showed significant anti-inflammatory effects on acute and chronic inflammation in a dose-dependent manner. Anti-inflammatory effect of TFTL was stronger than that of JLHT. The duration of anti-inflammatory effect of TFTL was longer than that of Asp.