异钩藤碱与天麻素合用对异钩藤碱在大鼠肝脏分布的影响

陈志远; 王兴; 李晓倩; 王新勇; 张卫国

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异钩藤碱与天麻素合用对异钩藤碱在大鼠肝脏分布的影响

更新时间：2024-01-04

- 异钩藤碱与天麻素合用对异钩藤碱在大鼠肝脏分布的影响
- Distribution of Isorhynchophyline in Liver Tissures before and after Compatibility with Gastrodin and Isorhynchophylline in Rats
- 中国实验方剂学杂志 2012年18卷第20期页码：193-196
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目(30801547);中央高校基本科研业务费专项资金项目(SWJTU11ZT26,SWJTU09ZT29)
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- 纸质出版日期：2012
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陈志远, 王兴, 李晓倩, 等. 异钩藤碱与天麻素合用对异钩藤碱在大鼠肝脏分布的影响[J]. 中国实验方剂学杂志, 2012,18(20):193-196.

CHEN Zhi-yuan, WANG Xing, LI Xiao-qian, et al. Distribution of Isorhynchophyline in Liver Tissures before and after Compatibility with Gastrodin and Isorhynchophylline in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(20): 193-196.
陈志远, 王兴, 李晓倩, 等. 异钩藤碱与天麻素合用对异钩藤碱在大鼠肝脏分布的影响[J]. 中国实验方剂学杂志, 2012,18(20):193-196. DOI：

CHEN Zhi-yuan, WANG Xing, LI Xiao-qian, et al. Distribution of Isorhynchophyline in Liver Tissures before and after Compatibility with Gastrodin and Isorhynchophylline in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(20): 193-196. DOI：

摘要

目的: 观察天麻素与异钩藤碱合用前后异钩藤碱在SD大鼠肝脏的分布变化。方法: 采用高效液相色谱法测定异钩藤碱与天麻素合用前后异钩藤碱在SD大鼠肝脏中的含量。色谱条件:WatersTM色谱柱(4.6 mm×250 mm

RP 18.5 μm);流动相甲醇-水(70∶30)

pH 8.0

流速0.8 mL·min-1

柱温30 ℃

检测波长 254 nm

进样量20 μL。结果: 异钩藤碱对照品在肝脏组织中在0.16~4.0 mg·L-1具有较好的线性关系;异钩藤碱与天麻素配伍前后在肝脏中的分布无显著性差异。结论: 天麻素有一定的降低异钩藤碱在肝脏分布的作用。

Abstract

Objective:To observation the distribution of isorhynchophyline in liver tissues before and after compatibility with gastrodin and isorhynchophylline in rats. Method: HPLC was employed to determinate the isorhynchophyline in liver tissuesin rats before and after compatibility with gastrodia and unicaria;analyticalcolumn was WatersTM(4.6 mm×250 mm

RP 18.5 μm); the mobile phase consisted of methanol-water (70∶30)

pH 8.0

fluid rate was 0.8 mL·min-1; the column temperature was 30 ℃

the detector wave length was set at 254 nm

the sample amount is 20 μL. Reslut: Isorhynchophyline in liver and kidney tissues was linear in the range of 0.16-4.0 mg·L-1. There were no significant differences in liver tissues of SD rats before and after compatibility. Conclusion: Gastrodin has a certain effects reduction in the liver tissues distribution.

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