Objective: To study acute toxicity

anti-inflammatory effect of water extract of the root of Sauropus rostratus. Method: Determined the LD50 of the water extract by modified Karber's method

Dimethylbenzene-induced auricle edema in mice

capillary permeability induced by acetic acid and cotton ball-induced granuloma in mice were respectively performed to investigate the anti-inflammatory effect of root of S. rostratus. Result: The LD50 of water extract of root of S. rostratus. was 152.24 g·kg-1. The auricle edema induced by dimethylbenzene in mice

capillary permeability induced by acetic acid and catton ball-induced granuloma in mice were inhibited significantly by water extract of root of S. rostratus. (P<0.05 or P<0.01). Conclusion: The water extract of root of S. rostratus. Had low toxicity and had anti-inflammatory effect. The researches provided a scientific basis for the developping and utilizing of S. rostratus.