Objective: To investigate the characteristics of drug application and combinational law of prescription in Gudao disease of Zhuang medicine. Method: Two hundred and seven prescriptions for Gudao disease in Zhuang medicine were collected

and the database containing the prescription information was established and analyzed with association rules. Result: Of the total 437 Zhuang herbs using in the 207 prescription

the top 15 high frequency Zhuang herbs

such as Rhizoma Iridis lectori

Exocarpium Citri Rubrum and Herba Tadehagi Triquetri

etc account for 1 452 times of total frequency. The association rule analysis showed that there were 12

9 and 6 rules meet the requirement of minimum sport and the minimum confidence in bigeminy herbs

trigeminy herbs and tetragenus herbs using

respectively. Conclusion: Application of association rules analysis on discovery the inherent law of the Gudao disease was a practicability and the result can provide theoretical guide for clinical practice.