LIU Wen, SI Na, YANG Song, et al. Investigation of Synchronous Release of Gastrodin and Turpentine Alcohot-biglucosid from Tianma Gouteng Decoction Oral Sustained Release Tablet[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(23): 46-48.
LIU Wen, SI Na, YANG Song, et al. Investigation of Synchronous Release of Gastrodin and Turpentine Alcohot-biglucosid from Tianma Gouteng Decoction Oral Sustained Release Tablet[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(23): 46-48.DOI:
采用相似因子进行释放曲线相似性比较。 结果: 天麻钩藤饮口服缓释片中天麻素和松脂醇二葡萄糖苷在体外可持续释放12 h
且具有同步性。 结论: 天麻钩藤饮缓释片具有同步缓释的溶出特点
天麻素和松脂醇二葡萄糖苷的释放具有相似性。
Abstract
Objective: To study on synchronous release of gastrodin and turpentine alcohot-biglucosid from Tianma Gouteng decoction sustained release tablet
and provide experimental basis for formulation reform of Tianma Gouteng decoction. Method: In vitro dissolution was investigated by rotating basket method
the content of gastrodin and turpentine alcohot-biglucosid were determined by HPLC
similar factor was adopted for comparing similarity of drug release curve by calculating cumulative dissolution ratio of medicinal components. Result: Gastrodin and turpentine alcohot-biglucosid could suatained relese 12 h in vitro
and had synchronization. Conclusion: Tianma Gouteng decoction sustained release tablet had dissolution characteristics of sustained release
release of gastrodin and turpentine alcohot-biglucosid had similarity.