Objective: To observe the clinical effect and the safety of Wenshen Kaiyu Tongbi Tang (WSKYTBT) on chest stuffiness and pain with heart-kidney yang deficiency. Method: Using prospective method

78 patients with chest stuffiness and pain with heart-kidney yang deficiency were divided into two groups randomly. The treatment group of 41 patients was given modified self-designed WSKYTBT

and the control group of 37 patients was given Chinese herbs of Huoxue Huayu. The period of treatment was 4 weeks. Items such as symptoms

angina attack

electrocardiogram

cardiac function

adverse reactions were examined before treatment and after treatment. Result: In the treatment group significant efficiency rate and total efficacy rate of clinical symptom of angina pectoris was 68.3%

97.6%

in the control group they were 45.9%

75.7% (P<0.05). In the treatment group significant efficiency rate and total efficacy rate of ECG were 63.4%

95.1%

while in the control group they were 37.8% and 73.0% (P<0.05). On the aspect of the effect on syndrome

significant efficiency rate and total efficacy rate were 68.3% and 97.6% in the treatment group

whle 45.9% and 75.7% in the control group (P<0.05). Conclusion: WSKYTBT can effectively improve the clinical symptoms of the patients with chest stuffiness and pain with heart-kidney yang deficiency

and it is safe and reliable as well.