Objective: To investigate influence of Didang decoction on the low extremity vascular disease of STZ-induced diabetic rats. Method: After being injected streptozotocin (STZ) into the caudal vein and fed with the high fat diet

diabetes model rats were divided into normal control group

model control group

Didang decoction group

and the rosiglitazone group. After continuous stomach perfusion administration for 12 weeks

the change of blood glucose

total urinary protein in 24 h

serum creatinine were detected with correlative methods

and the expression of intercellular adhesion molecule-1(ICAM-1) in kidney were examined by inmunohistochemical technique. Result: Compared with normal control group

the expression of ICAM-1 in model control group is significantly increased.Compared with model control group

the expression of ICAM-1 is decreased in Didang decoction group

and rosiglitazone group. Conclusion: Didang decoction can restrain expressions of ICAM-1 on kidney

maybe one of the possible mechanisms.