Objective: To study the anti-senility effects of Liuwei Xueha tablets in aged rats in order to provide clinical & medicinal basis for its application in weak & elderly patients. Method: Fourty 15-month-old rats were divided into 4 groups at random: the control group and Liuwei Xueha tablets groups

low ( 0.36 g·kg-1)

middle (0.72 g·kg-1) and high dosages (1.44 g·kg-1)

all groups were orally treated for 60 days. The effects on the rat weight indexes

superoside dismutase(SOD) activities in liver

the malandialdehyde(MDA) contents and glutathione peroxidase(GSH-Px) activities in serum were observed. Result: The tablets showed no obvious effects on elder female rats' weight and ascending SOD activities

but it had clear effects of lowering MDA content and raising GSH-Px activities. Conclusion: Liuwei Xueha tablets has anti-senility effects

which may be related with its functions of radicals scavenging and MDA contents decreasing.