Objective: To investigate immunization and the anti-inflammatory effect of Artemisia rupestris granule to provide the reference for the clinical treatment of influenza. Method: Mice were randomized into the model group

antiviral granule group and Artemisiae rupestris granules group with 1

2

4 g·kg-1 dose respectively using the xylene-induced mouse ear edema and capillary permeability test to investigate anti-inflammatory effects. The efects on the immune function of drug were measured by ELISA in serum of mice immunized with sheep red blood cell(SRBC) IgM-generated effects

and drugs on effects of Lipopoly saccharide LPS and ConA induced T

B lymphocyte proliferation was measured by MTT colorimetric assay. Result: Artemisia compound particles 2

4 g·kg-1 dose could significantly inhibited xylene-induced ear edema in mice; Artemisia rupestris granule (1

2

4 g·kg-1 dose)could significantly inhibited acetic acid-induced increase in capillary permeability in mice and significantly increased levels of serum IgM antibodies of SRBC immunized mice; Artemisia rupestris granule 232-15 000 mg·L-1 concentration range can suppress ConA-induced T cell proliferation (P<0.05); Artemisia rupestris granule 464-15 000 mg·L-1 concentration range can significantly suppress LPS-induced B lymphocyte proliferation (P<0.05). Conclusion: Artemisiae rupestris granules have anti-inflammatory and immunoregulation function.