丁香挥发油对磷酸川芎嗪贴剂的经皮促渗作用

罗红梅; 马云淑; 黄金娥; 张贵华; 康绍建

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丁香挥发油对磷酸川芎嗪贴剂的经皮促渗作用

更新时间：2024-01-04

- 丁香挥发油对磷酸川芎嗪贴剂的经皮促渗作用
- Percutaneous Enhancement Function of Volatile Oil from on Ligustrazine Phospate Patch
- 中国实验方剂学杂志 2012年18卷第11期页码：40-43
- 作者机构：
- 作者简介：
- 基金信息：
  
  云南省科技计划项目(2008CD152);国家自然科学基金项目(30960517)
- DOI：
  中图分类号：
- 纸质出版日期：2012
- 稿件说明：
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罗红梅, 马云淑, 黄金娥, 等. 丁香挥发油对磷酸川芎嗪贴剂的经皮促渗作用[J]. 中国实验方剂学杂志, 2012,18(11):40-43.

LUO Hong-mei, MA Yun-shu, HUANG Jin-e, et al. Percutaneous Enhancement Function of Volatile Oil from on Ligustrazine Phospate Patch[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(11): 40-43.
罗红梅, 马云淑, 黄金娥, 等. 丁香挥发油对磷酸川芎嗪贴剂的经皮促渗作用[J]. 中国实验方剂学杂志, 2012,18(11):40-43. DOI：

LUO Hong-mei, MA Yun-shu, HUANG Jin-e, et al. Percutaneous Enhancement Function of Volatile Oil from on Ligustrazine Phospate Patch[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(11): 40-43. DOI：

摘要

目的: 考察不同质量分数的丁香挥发油对磷酸川芎嗪贴剂的经皮促渗作用。方法: 用改良Franz扩散池法

以氮酮为阳性对照

不含促渗剂的磷酸川芎嗪贴剂为阴性对照

考察含3%

10%的丁香挥发油对模型药磷酸川芎嗪经小鼠皮肤的促渗效果

采用HPLC测定磷酸川芎嗪的含量。结果: 4种质量分数的丁香油对磷酸川芎嗪12 h平均累积渗透量(Q12)分别为3.030

4.066

1.845

1.205 mg·cm-2;其12 h时增渗倍数分别为1.54

2.06

0.96

0.62。与阴性对照组的Q12比较

5%丁香油与3%丁香油促渗作用显著。结论: 3%

5%的丁香油能明显提高磷酸川芎嗪在贴剂中的渗透量

且促渗效果好。

Abstract

Objective: To investigate percutaneous penetration effect of different concentration of volatile oil from Eugenia caryophyllata on ligustrazine phosphate (LP). Method: Modified Franz diffusion cell method was used

with azone as positive control

LP without penetration enhancers as negative control

penetration effect of 3%

7% and 10% volatile oil from E. caryophyllata on LP through mouse skin were investigated

the content of LP was determined by HPLC. Result: Average cumulative permeation volume(Q12)of the 4 concentrations of volatile oil from E. caryophyllata on LP in 12 h were 3.030

4.066

1.845 and 1.205 mg·cm-2

respectively;and enhancing rates (ER) in 12 h were 1.54

2.06

0.96 and 0.62

respectively.Compared with Q12 of negative control group

5% and 3% volatile oil from E. caryophyllata had significantly enhancing effect. Conclusion: 3% and 5% volatile oil from E. caryophyllata could enhance permeation volume of LP through mouse skin obviously

and had great enhancing effect.

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