Objective: To evaluate genotoxicity of Radix Millettiae Speciosae by single cell gel electrophoresis. Method: Forty mice were divided into five groups randomly: negative control group

positive control group

and Radix Millettiae Speciosae group with high(20 g·kg-1)

middle (10 g·kg-1)or low(5 g·kg-1) doses. Radix Millettiae Speciosae groups were given with relative drugs

Negative control group and positive control group were given with normal saline by gavage once a day for 10 days

while the last two days

positive control group was injected with cyclophosphamide(0.08 g·kg-1)once a day. In the eleventh day

the mice were sacreficed

DNA damage of liver

kidney

lung

testicular cells was detected by single cell gel electrophoresis. Result: Compared with positive control group

tail DNA% and tail moment of liver

kidney

lung

testicular cells in Radix Millettiae Speciosae group had a significant lowereduction (P<0.01).Compared with the negative control group

tail DNA%and tail moment of kidney cells in the Millettiae Speciosae group with high dose showed a significant reduction (P<0.05)

tail moment and tail DNA% of ther cells in other dose group

no statistically significant difference was found. Conclusion: Radix Millettia Speciosa has no damage to mouse cells DNA.