Objective : To observe the influence of Bangxiong Shufeng granlues on the experimental migraine. Method: The mice was divided into blank control group

model group

three doses groups of Bangxiong Shufeng granlues (9.75

19.5

39 g·kg-1·d-1)

Chinese medicine and western medicine control groups. The chemical and physical pain threshold were observed nitroglycerin was used to make rat migraine model

the change of behavior and plasma serotonin (5-HT) were detected. Result: In test of mice tail flick. Bangxiong Shufeng granlues with high dose increased the pain threshold at 30

60

90

120 min

respectively (P<0.05 or P<0.01). In acetic acid induced writhing model

Bangxiong Shufeng granlues with medium and high dose decreased writhing frequency. In the test of migraine model by nitroglycerin. Bangxiong Shufeng granlues with low

medium and high dose decreased disappeared time of red eras and

high dise group decreased the frequency of scratching head and climbing cage frequency during the period of 30 to 80 min and 30 to 180 min compared with model group

the treatment group increased 5-HT content. Conclusion: Bangxiong Shufeng granlues would have effects on migraine model.