Objective: To study the anti-tumor effect of resveratrol-solid lipid nanopartieles(Res-SLN)on mouse H22 hepatocellular carcinoma in vivo. Method: KM mice bearing H22 tumor cells were used in this study. It were randomly divided into tumor model group;CTX group(25 mg·kg-1);low

middle

high dosage groups of Res-SLN(35

70

105 mg·kg-1);suspensions group of Res(105 mg·kg-1); auxiliary materials group.The anti-tumor activity of Res-SLN on solid tumor mice was evaluated by tumor mass weight and tumor inhibitory ratio

and the life-prolongation effect on ascitic tumor mice was assessed by average survival time. The influence on the immune organs was evaluated by the indexes of thymus and spleen of mice with transplanted tumor. Result: Res-SLN had significant inhibiting effect on transplanted tumor growth in mice. Inhibitory rates of Res-SLN in low

middle

high dose groups on H22 mice were 61.95%

72.39%

85.52%

respectively. The differences of indexes of thymus and spleen were insignificant between the ORI-SMEDDS group and model control group. Res-SLN in the middle

high doseage groups had an effect on prolonging the life of mice with transplanted tumor

the statistical difference being significant as compared with the model group. Conclusion: Res-SLN shows certain inhibition on the growth of transplanted H22 tumor with dose-dependence

and the inhibitory effect is stronger than oridonin.