ZHANG Ai-li, BI Yu-an. Molding Process and Dissolution of Tianshu Dripping Pills[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(20): 11-13.
ZHANG Ai-li, BI Yu-an. Molding Process and Dissolution of Tianshu Dripping Pills[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(20): 11-13.DOI:
Objective: To optimize preparation technology of Tianshu dropping pills and to establish determination method of its dissolution in vitro. Method: Spherical degree
pill weight and time of dissolution as indexes
influential factors were investigated by orthogonal design.Small vessel and HPLC method were applied to determine dissolution of ferulic acid. Result: The optimal conditions were as follows: drug-matrix1 ∶2
PEG6000-S40 3 ∶1
coolant nozzle temperature was 25-30 ℃
dripping rate was 60-65 d·min-1;Accumulated dissolution percentage of ferulic acid reached over 85% in 10 min
and dissolved completely within 15 min. Conclusion: This process is reasonable and favorable for industrial production