Objective: To study on transfer rate of chlorgenic acid in preparation process of Yinqiao Jiedu soft capsules

and to provide experimental data for preparation process optimization and quality control. Method: According to prescription and technology of Yinqiao Jiedu soft capsules contained in Pharmacopoeia

transfer rate and retention rate of chlorgenic acid in preparation process of Yinqiao Jiedu soft capsules were determined by HPLC. Meanwhile

the content of chlorgenic acid in 3 batches of Yinqiao Jiedu soft capsules were determined by HPLC. Result: Preparation process contained 4 steps: ethanol refluxing

decompression concentration

addition of other herbs’ thickpaste and desiccation

addition of naphtha and bean oil. The mean transfer rate of chlorgenic acid in above steps were 86.1%

77.5%

73.2% and 72.8%;and mean retention rate were 86.1%

90.0%

94.6% and 99.3% respectively. The content of chlorgenic acid in per capsule of Yinqiao Jiedu soft capsules with three batches were 3.77

3.38

3.86 mg. Conclusion: This study could provide reference for quality control and content limit standard establishment in preparation process of Yinqiao Jiedu soft capsules.