Objective: To observe the effect of Shuyu Wan on the immunity of murine AIDS(MAIDS)induced by the Friend murine leukemia virus(FLV). Method: Experimental model was established by inoculated intraperitoneally(ip)with FLV in mice. Meanwhile

treatment groups were intragastric administrated with Shuyu Wan. Three weeks later

blood was withdrawn to assay interleukin-2(IL-2)

interferon(IFN)-γ and IL-6 by enzyme linked immunosortent assay(ELISA). Percentage of cluster of differentiation 4+(CD4+)T lymphocyte and CD8+T lymphocyte were determined by flow cytometry. In addition

some mice were injected cyclophosphamide(CTX)and given Shuyu Wan for 5 days

then

leucocytes

hemoglobins

and erythrocytes were dectected. Result: FLV model group showed no evident differences to the treatment groups. But compared with CTX group

the amount of leucocytes

hemoglobins

and erythrocytes were higher markedly in Shuyu Wan groups(P<0.05). Conclusion: Shuyu Wan could not ameliorate immunity of MAIDS induced by the Friend murine leukemia virus. Friend virus infection model might not be appropriate for anti-HIV study by traditional Chinese medicine.