Objective: To explore the effect of total alkaloids in Leonuri Herba(LH) on mice benign prostate hyperplasia (BPH). Method: Benign prostatic hyperplasia model was established by subcutaneous injecting of testosterone propionate 5 mg·kg-1·d-1 consecutively for 21 d. The mice were randomly divided into 6 groups:160

80

40 mg·kg-1 alkaloids dosage group

Longbishu capsule suspension group

model group. normal control group. Every group was daily given the corresponding drugs for 30 days. The prostate index and histomorphology changes of prostate gland

testicle

epididymis

thymus gland and spleen that were determined. Result: Compared with model group

the total alkaloids in LH at the dosage of 160

80

40 mg·kg-1 could significantly reduce the prostate index of BPH. The prostate index of different groups was (0.53±0.1). (0.51±0.1)

(0.64±0.18) mg·g-1 respectively.The total alkaloids in LH could significantly improve the pathological changes of testicle and epididymis concomitant with BPH. The total alkaloids in LH at the dosage of 160

80

40 mg·kg-1could significantly improve the atrophy of thymus gland and spleen. The thickness of thymus cortical and the number of lymphocyte was (24.16±2.2)

(26.28±3.20)

(26.32±3.31) μm and (60.3±4.5)

(68.2±5.2)

(53.3±4.2). The spleniclymphnodules and the number of lymphocyte was respectively(14.18±2.3)

(16.14±3.0)

(29.26±3.52) μm and (17.2±2.0)

(15.3±3.1)

(28.3±3.4). Conclusion: Total alkaloids in LH has good therapeutic actions on mice BPH.