异长春花碱脂质体的制备及安全性评价

程岚; 李学涛; 唐凌

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异长春花碱脂质体的制备及安全性评价

更新时间：2024-01-04

- 异长春花碱脂质体的制备及安全性评价
- Preparation and Safety Evaluation of Vinorelbine Liposems
- 中国实验方剂学杂志 2011年17卷第20期页码：241-244
- 作者机构：
- 作者简介：
- 基金信息：
  
  辽宁中医药大学青年药学人才基金(yxrc0911)
- DOI：
  中图分类号：
- 纸质出版日期：2011
- 稿件说明：
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程岚, 李学涛, 唐凌. 异长春花碱脂质体的制备及安全性评价[J]. 中国实验方剂学杂志, 2011,17(20):241-244.

CHENG Lan, LI Xue-tao, TANG Ling. Preparation and Safety Evaluation of Vinorelbine Liposems[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(20): 241-244.
程岚, 李学涛, 唐凌. 异长春花碱脂质体的制备及安全性评价[J]. 中国实验方剂学杂志, 2011,17(20):241-244. DOI：

CHENG Lan, LI Xue-tao, TANG Ling. Preparation and Safety Evaluation of Vinorelbine Liposems[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(20): 241-244. DOI：

摘要

目的: 制备异长春花碱(vinorelbine VRB)脂质体

并对其安全性进行初步评价。方法: 采用薄膜分散法制备VRB脂质体

对VRB脂质体的急性毒性、血管刺激性及溶血性等安全因素进行考察

并以VRB注射液为对照

比较2种制剂的半数致死量(LD50)、溶血性及血管刺激性等指标。结果: 所制备的VRB脂质体平均粒径158.3 nm

包封率为85.3％;VRB脂质体及注射液的LD50 分别为16.02

4.16 mg·kg-1;与注射液比VRB脂质体不引起家兔溶血和红细胞聚集反应

静脉注射对家兔血管刺激性较VRB注射液减轻。结论: 所制备的VRB脂质体粒径均匀

形态圆整

包封率符合《中国药典》要求

并且和注射液比具有较高的安全性。

Abstract

Objective: To prepare the vinorelbine liposomes(VL) and investigate its safety. Method: Liposomes was prepared by thin-film ultrasonication method.The acute toxicity of VL was evaluated in Kunming mice.Its vein irritation and hemolysis was characterized in rabbits.Vinorelbine injection(VI) was taken as the control.LD50

vein irritation and hemolysis of these two preparations was compared. Result: The particle size of the liposome was 158.3 nm; The bilayer of the liposome was seen clearly; and the entrapment efficiency was 85.3％.The LD50 of VL and VI in mice was 16.02

4.16 mg·kg-1 respectively.None of hemolysis

hemagglutination and vein irritation was observed after intravenous injection of VL into rabbits. Conclusion: Compared with VI

VL was safer and more efficient.

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