Objective: Flexible nanoliposomes was prepared with proanthocyanidins to study the relationship between deposition and time of proanthocyanidins in rats'abdominal skin and its topical pharmacokinetics. The function of flexible nanoliposomes in enhancing the transdermal absorption of the encapsulated drug was investigated. Method : Flexible nanoliposomes was prepared with proanthocyanidins using a film dispersion method to determine the relationship between deposition and time of proanthocyanidins in rats' abdominal skin by ultraviolet spectrophotometry

and the pharmacokinetic parameters were fitted by DAS. Result : Depositions of different time in rats' abdominal skin could be fitted with the two compartment model. Conclusion : The active ingredients of proanthocyanidins flexible nanoliposomes can permeate through the skin effectively and lie long time.