Objective: To study the effect of Heibu ointment on the expression of type I and type Ⅲ collagen and MMP-1 mRAN in the hypetrrophic scarof rabbit ear. Method : Twenty-four white rabbits were randomly divided into the normal control group

Heibu ointment treatment group and model group. Heibu ointment treatment group and model group were used to establish the models of hypertrophic scar in ears.After twenty-one days

Heibu ointment (1 g) was plastered on the hypetrrophic scar in Heibu ointment treatment group and on the skin in the normal control group once every three days for 56 days. The tissure material was respectively taken on the second

the fourth

the sixth and the eighth week

the expression of type I and type Ⅲ collagen and MMP-1 mRAN were detected by real time PCR(RT-PCR) technique. Result : Compare with the model group

the expression of type I collagen mRAN was obviously weaker (P<0.01)

the expression of type Ⅲ collagen and MMP-1 mRAN was increased in the Heibu ointment treatment group(P<0.01). Conclusion : Heibu ointment could inhibit the expression of type I collagen mRAN and promote the expression of type Ⅲ collagen and MMP-1 mRAN

thus it could inhibit the proliferation of hypertrophic scar of the rabbit ear.This maybe one of the mechanisms that the Heibu ointment inhibit the proliferation of hypertrophic scar of rabbit ear.