Objective: To study the effect of extract from Munronia henryi Harms(MhH) on anti-inflammation and analgesia and to observe its acute toxicity. Method: Hot-plate procedure and writhing test in mice were adopted in experimental analgesic models

and anti-inflammatory model of mouse ear edema induced by xylene

rat paw edema induced by carrageenin and exudation of abdominal blood capillaries of mice were applied. The median lethal dose(LD50) was determined. Result: MhH (80

40 mg·kg-1

qd×1) could significantly prolong the pain threshold on hot-plate in mice

reduce the writhing times in mice. It could significantly inhibit the ear edema caused by xylene in mice

rat paw edema induced by carrageenin

and exudation of abdominal blood capillaries in mice caused by acetic acid (80

40

20 mg·kg-1

qd×3).The LD50 of MhH was 478.9 mg·kg-1

its 95% confident limit was 446.8-513.2 mg·kg-1. Conclusion: MhH has obvious effect on anti-inflammation and analgesia and its acute toxicity is low.