Objective: To study protective effects of total polyphenols from the seeds of Toona sinensis (TSTP)on hepatic injury at early stage in diabetic rats. Method: Diabetic models were induced by once intraperitoneal injection of STZ (55 mg ·kg-1).Then the blood glucose was detected after 72 hours. when hypoglycemic point>11.1 mmol ·L-1 the rats model were successful. Diabetic rats were randomly divided into model group

glibenclamide group(10 mg ·kg-1) and high-(75 mg ·kg-1) and low(45 mg ·kg-1)-doses of TSTP groups. At the same time

8 rats were choosen as normal group. All groups were fed qd for 14 consecutive. At fifteen day

all rats were anaesthetized and then were killed to remove Hepars and collect the blood sample. The fasting blood glucose(FBG)

AST

ALT were detected. the liver index was calculated. The pathological changes of the liver were evaluated with HE. Result: TSTP can decrease FBG. High-and low-doses of TSTP groups FBG at 7 days were (11.79±2.75)

(12.55±3.35) mmol ·L-1and at 14 day were (10.18±2.34)

(11.80±2.74) mmol ·L-1

Compared to modles

the FBG decreased(P< 0.05

P< 0.01);ALT and AST did not decrease. High dose group decrease liver index(3.616±0.358 3)

improve pathological morphous. Conclusion: TSTP has a protective effect on liver injury at early stage in diabetic rats.