Objective: To study the effects of Cheng’s Fenqingyin on the rats with nephritic syndrome. Method: Fifty male SD rats were randomLy divided into five groups (ten for each group):the normal control group(A)

model control group(B)

Cheng’s Fenqingyin group(C)

hormone group(D) and Cheng’s Fenqingyin +hormone group(E). Rats model with nephritic syndrome was established by one-time caudal vein injection of Adriamycin (5.5 mg ·kg-1). The effects of the Cheng’s Fenqingyin on the rats with nephritic syndrome were observed in the urine protein

serum albumin(Alb)

blood urea nitrogen(BUN)

serum creatinine(Cr)

serum triglyceride(TG) and pathological kindney. Result: The 24 h urine protein in the treatment groups was significantly lower than in group B (P<0.05

P<0.01). Serum biochemical indicators in each treatment group significantly improved in contrast to group B. The kindney significantly changed. Conclusion: Cheng’s Fenqingyin can effectively improve the urine protein and lipid metabolism of the nephritic rats

protect the renal function and reduce the renal injury

so Cheng’s Fenqingyin is proved to have remedial effect for Rats with nephritic syndrome.