Objective: To observe the effect of Tangzhiping granules on NO

NOS and morphological changes of kidney tissue in diabetes mellitus (DM) Wistar rats with nenopathy. Method: The diabetic nenopathy model of rats with was successfully made by high adipose diet and injection of streptozocin (STZ) in abdominal cavity.Then the rats were intervened withTangmaikang granules and Tangzhiping granules and the contents of NO and NOS were detected.The morphological changes in kidney tissue wereobserved. Result: After treatment

and the contents of NO and NOS in kidney in the treatment groups were increased significantly compared with that of the model (P<0.05)

The contents of NO and NOS in the Tangzhiping high dose group were increased significantly compared with those in the positive drug group and in the Tangzhiping low dose group (P<0.05).Morphological slides showed that the Tangzhiping high and low doses and the positive control drug had protective effect on injury caused by diabetic nenopathy.The protection come from the Tangzhiping high dose was the most. Conclusion: Tangzhiping granules can increase NO and NOS in rats with diabetic nenopathy and promote the kidney tissue repairs at the same time.