普胃丸对慢性胃溃疡大鼠胃组织中EGF和EGFR蛋白表达的影响

王会丽; 贾欣; 白静; 赵雷; 吕华; 齐亚娟

您当前的位置：

首页 >

文章列表页 >

普胃丸对慢性胃溃疡大鼠胃组织中EGF和EGFR蛋白表达的影响

更新时间：2024-01-04

- 普胃丸对慢性胃溃疡大鼠胃组织中EGF和EGFR蛋白表达的影响
- Effects of Puwei Pill on Expressions of Epidermal Growth Factor and Epidermal Growth Factor Receptor Protein in Gastric Tissue in Rats with Chronic Gastric Ulcer
- 中国实验方剂学杂志 2011年17卷第12期页码：148-150
- 作者机构：
- 作者简介：
- 基金信息：
  
  河北省唐山市科学技术研究与发展计划课题(08360202A-3)
- DOI：
  中图分类号：
- 纸质出版日期：2011
- 稿件说明：
移动端阅览
王会丽, 贾欣, 白静, 等. 普胃丸对慢性胃溃疡大鼠胃组织中EGF和EGFR蛋白表达的影响[J]. 中国实验方剂学杂志, 2011,17(12):148-150.

WANG Hui-li, JIA Xin, BAI Jing, et al. Effects of Puwei Pill on Expressions of Epidermal Growth Factor and Epidermal Growth Factor Receptor Protein in Gastric Tissue in Rats with Chronic Gastric Ulcer[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(12): 148-150.
王会丽, 贾欣, 白静, 等. 普胃丸对慢性胃溃疡大鼠胃组织中EGF和EGFR蛋白表达的影响[J]. 中国实验方剂学杂志, 2011,17(12):148-150. DOI：

WANG Hui-li, JIA Xin, BAI Jing, et al. Effects of Puwei Pill on Expressions of Epidermal Growth Factor and Epidermal Growth Factor Receptor Protein in Gastric Tissue in Rats with Chronic Gastric Ulcer[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(12): 148-150. DOI：

摘要

目的: 考察普胃丸(Puwei Pill

PWP)对慢性胃溃疡(chronic gastric ulcer

CGU)大鼠胃组织中促增生因子表皮生长因子(Epidermal Growth Factor

EGF)和表皮生长因子受体(epidermal growth factor receptor

EGFR)蛋白表达的影响。方法: 将大鼠随机分为5组

即正常组、假手术组、模型组

PWP组和奥美拉唑肠浴片(OMLZ)组

用醋酸烧灼法建立大鼠CGU模型

通过灌注给药

于16 d后处死大鼠

然后分别采用免疫组化法和Western blot法

观察PWP对胃组织中EGF和EGFR蛋白表达的影响

考察PWP抗CGU的促黏膜增生机制。结果: 与模型组比较

PWP与OMLZ组EGF和EGFR的平均阳性密度均显著增加(P<0.01或P<0.05)

EGF和EGFR蛋白表达均显著提高(P<0.01或P<0.05)

PWP可明显增加胃组织中EGF和EGFR的蛋白表达。结论: PWP通过促进胃组织中EGF和EGFR的蛋白表达来发挥抗CGU的作用。

Abstract

Objective: To investigate the effects of Puwei Pill (PWP) on expressions of epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) protein in gastric tissue in rats with chronic gastric ulcer(CGU). Method: The animals were divided into five groups. CGU model was built by using acetic acid. Then the protein expressions of EGF and EGFR in gastric tissue was determined by immunohistochemical staining and western blot so as to evaluate the pro-mucoca growth mechanism underlying PWP resisting of CGU. Result: Compared with the model

PWP could obviously increase the expressions of EGF and EGFR protein in gastric tissue. Conclusion: PWP plays the role of resisting of CGU through increasing the expression of EGF and EGFR protein in gastric tissue.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

复方梭子蟹胶囊对大鼠胃溃疡模型的影响

溃结饮对UC大鼠血清EGF含量的影响

普胃丸对复发胃溃疡大鼠抗氧化及改善胃黏膜血流的作用

参七消痞颗粒对慢性萎缩性胃炎大鼠血清GH,EGF,GAS的影响