阿特拉津及其主要代谢物在大鼠体内的组织分布

梁秋云; 朱丹; 黄慧学; 谭珍媛

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阿特拉津及其主要代谢物在大鼠体内的组织分布

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- 阿特拉津及其主要代谢物在大鼠体内的组织分布
- Tissue Distribution of Atrazine and Its Main Metabolite in Rat
- 中国实验方剂学杂志 2011年17卷第9期页码：222-225
- 作者机构：
- 作者简介：
- 基金信息：
  
  广西教育厅项目(200911MS135);广西中医学院中药药效研究重点实验室开放课题(09-007-06-16)
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- 纸质出版日期：2011
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梁秋云, 朱丹, 黄慧学, 等. 阿特拉津及其主要代谢物在大鼠体内的组织分布[J]. 中国实验方剂学杂志, 2011,17(9):222-225.

LIANG Qiu-yun, ZHU Dan, HUANG Hui-xue, et al. Tissue Distribution of Atrazine and Its Main Metabolite in Rat[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(9): 222-225.
梁秋云, 朱丹, 黄慧学, 等. 阿特拉津及其主要代谢物在大鼠体内的组织分布[J]. 中国实验方剂学杂志, 2011,17(9):222-225. DOI：

LIANG Qiu-yun, ZHU Dan, HUANG Hui-xue, et al. Tissue Distribution of Atrazine and Its Main Metabolite in Rat[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(9): 222-225. DOI：

摘要

目的: 建立HPLC测定大鼠血浆和组织中阿特拉津(ATR)及其主要代谢物脱乙基脱异丙基阿特拉津(DEDIA)的浓度

研究ATR及DEDIA在大鼠组织的分布特征。方法: 大鼠单剂量灌胃ATR

分别在给药后0.5

6和12 h取血和组织样本

以乙腈沉淀蛋白

0.5%冰醋酸甲醇液-0.5%冰醋酸水溶液梯度洗脱

HPLC测定样品浓度。结果: ATR在体内被快速且大量的代谢为DEDIA

血浆和组织中均能检测到ATR和DEDIA

尤以DEDIA为主;DEDIA在各组织中广泛分布

但消除速率不一

以肝、肾消除速度最慢。结论: ATR及DEDIA在大鼠各组织中的分布及消除规律

可为临床毒代动力学提供参考。

Abstract

Objective: To develop an HPLC method for the determination of atrazine (ATR) and its main metabolite (DEDIA) in rat plasma and tissues

and to study tissue distribution. Method: Rats were oral administrated atrazine at a single dose

blood and tissues samples were collected at 0.5

6 and 12 h after administration. After precipitated protein with acetonitrile

an HPLC-UV method was established to determine the concentration of ATR and DEDIA

the analytes were eluted by gradient solvent of MeOH/H2O which contained 0.5% acetic acid. Result: ATR was quickly and extensively metabolized to DEDIA in rat

ATR and DEDIA could be detected in plasma and tissues;DEDIA widely distributed in various tissues

but with varies elimination rates

especially slow in liver and kidney. Conclusion: Those distribution and elimination regular of ATR and DEDIA can provide references for toxicokinetics study.

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