Objective: To observe the effect of Fuzhi capsule on the ability of learning and memory and the hippocampus Ach E activity and CHAT content and the content of IL-6

TNF-ɑ in serum in rats with vascular dementia. Method: The rat model was established by blocking bilateral common carotid arteries permanently

and the model rats were randomly classified into two groups

i.e. Fuzhi Capsule group(4.5 g ·kg-1

ig) and model group. Then(3 d

7 d and 28 d after treatment) active avoid reaction(AAR)rate

hippocampus Ach E activity and CHAT content and the content of IL-6

TNF-ɑ in serum were observed. Such factors were detected as hippocampus Ach E activity and CHAT content in serum after treatment. Result: Cholinergic neurons in the hippocampus were damaged irreversibly after 3 d of ischemia-reperfusion. The Fuzhi Capsule could reduce the damage process in early stage but did not have significant improvement on the damaged cholinergic nerve in the course of treatment. The hippocampus Ach E content was increased significantly after 3 d

then at a low level. Then Fuzhi Capsule increased it in 7 d and 28 d by comparison with the sham operated group

decreased the expression of IL-6 in early ischemia-reperfusion obviously. The expression of TNF-ɑ were abnormal in the early and late inflammation stage. Then treatment of Fuzhi Capsule decreased it obviously comparison with that of the sham operated group. Conclusion: Fuzhi Capsule can improve the ability of learning and memory. This indicates that Fuzhi capsule may mitigate the injury of inflammation and regulate the low level of acetylcholine in hippocampus.