Objective: To screen the optimal formula for total flavonoids dispersible tablets of hawthorn leaves. Method: Different kinds of excipients in the prescription were selected and their amount was optimized by using disintegration time as parameters.The optimal composition of the prescription was determined by orthogonal design experiment. Result: The optimal formulation was as follows:16% total flavonoids extracts of hawthorn leaves

55% MCC

8% cCMC-Na

18% starch and 1% magnesium stearate.The disintegration time of dispersible tablet was (66±5)s. Conclusion: The dispersible tablet had reasonable prescription and its dissolution rate was much better than the common tablet of hawthorn leaves total flavonoids in the market.It would be a product worthy of exploitation and utilization.