超高压液相色谱-串联质谱法分析中药中甲胺磷残留物

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超高压液相色谱-串联质谱法分析中药中甲胺磷残留物

更新时间：2024-01-04

- 超高压液相色谱-串联质谱法分析中药中甲胺磷残留物
- Determination of Methamidophos in Herbs by Ultra Performance Liquid Chromatography Combined with Quadrupole Mass Spectrometry
- 中国实验方剂学杂志 2011年17卷第7期页码：72-73
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- 纸质出版日期：2011
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肖竦. 超高压液相色谱-串联质谱法分析中药中甲胺磷残留物[J]. 中国实验方剂学杂志, 2011,17(7):72-73.

XIAO Song. Determination of Methamidophos in Herbs by Ultra Performance Liquid Chromatography Combined with Quadrupole Mass Spectrometry[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(7): 72-73.
肖竦. 超高压液相色谱-串联质谱法分析中药中甲胺磷残留物[J]. 中国实验方剂学杂志, 2011,17(7):72-73. DOI：

XIAO Song. Determination of Methamidophos in Herbs by Ultra Performance Liquid Chromatography Combined with Quadrupole Mass Spectrometry[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(7): 72-73. DOI：

摘要

目的: 建立中药材中甲胺磷残留物的测定方法。方法: 采用超高压液相色谱-串联质谱(UPLC-MS/MS)联用技术

采用Acquity UPLC BEHC18(2.1 mm×50 mm

1.7 μm)

乙腈-0.1%甲酸为流动相

梯度洗脱

以保留时间和离子对进行定性和定量

在ESI(+)和MRM监测模式下进行样品分析。结果: 在0.5~10.0 mg ·L-1

线性关系良好

回收率99.53%

RSD 2.1%。结论: 该法样品前处理简单、分析速度快、回收率和灵敏度高。

Abstract

Objective: To establish a method for determination of methamidophos in herbs. Method: The content of methamidophos in herbs was determined by UPLC-MS/MS. The chromatographic analysis was performed on an Acquity UPLC BEHC18 (2.1 mm×50 mm

1.7 μm) by a gradient elution employing of acetonitrile-0.1% formic acid. The analytes were detected using electrospray ionization tandem mass spectrometry with multiple reaction monitoring (MRM) in positive ion scan mode. Result: The linear range of methamidophos was 0.5-10.0 mg ·L-1. The average recovery was 98.53% and RSD was 2.1%. Conclusion: The method was simple

sensitive

accurate and short of analytical cycle.

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