Objective: To study the inhibitory effect against Staphylococcus aureus of 19 Chinese herbal drug Compound Prescriptions from《Treatise on Exogenous Febrile》. Method: Serum as obtained from the mice which were infected by Staphylococcus aureus inoculated in abdomen and those which were not infected.The inhibitory effect against Staphylococcus aureus of the serum were tested and compared.Then 19 Chinese herbal drug compound prescriptions chosen from 《Treatise on Exogenous Febrile》 was fed to the mouse which were infected by Staphylococcus aureus and their serum was tested to verify the inhibitory effect against Staphylococcus aureus. Result: Result shows that Staphylococcus aureus can consume lots of the anti-bacterial substances in the body

thus reduce the level of anti-bacterial capacity of those mice infected by Staphylococcus aureus

compared to those non-infected

and 19 Chinese herbal drug compound prescriptions can reverse the process. Conclusions: The listed Chinese herbal drug compound prescriptions can restore the inhibitory capacity of the body againt Staphylococcus aureus.