Objective: To condense the remedy and improve the therapeutic effect of Xiezhuo Chubi decoction experimentally

in order to provide reference for development of traditional Chinese medicine for hyperuricemia. Method: The mouse model of hyperuricemia was established by using hypoxanthine

then therapeutic effect of different compositions of Xiezhuo Chubi decoction on hyperuricemia was compared. Result: The uric acid in hyperuricemia mice was reduced significantly after treatment by Xiezhuo Chubi decoction. The high-dose group of two different compositions of Xiezhuo Chubi decoction could reduce the uric acid in normal mice. There was no significant difference between the two compositions. Conclusion: The different compositions of Xiezhuo Chubi decoction can reduce the uric acid on hyperuricemia in mice.