Objective:To set up a rat model of diabetic cerebral embolism

in order to observe and compare the expression of advanced glycosylation end product receptor(RAGE) in rat brain and effects about Huoluoyuyinfang Decoction on it.Methods: SD rats were fed on a diet enriched in fat and fructose and the rats were injected intrapertoneally with a low-dose streptozocin(STZ) to induce hyperglycemia.Then set up middle cerebral artery occlusion(MCAO) by ligation.Morphology and other methods were applied to observe the protective effect of Huoluoyuyinfang at different doses and differrnt times.Immunohistochemical ABC method was employed to observe the effect of Huoluoyuyinfang on RAGE in rat brain of cerebral infarction due to diabetes.Results: For different dosages and stages

the RAGE expression was significantly decreased in the brain tissue by Huoluoyuyinfang.Clusion: Huoluoyuyinfang Decoction may decrease the expression of RAGE and play an important protecting role against diabetic neurological impairment.