4种活血化瘀中药有效成分对血管紧张素Ⅱ诱导的血管外膜成纤维细胞增殖及胶原合成的影响

鹿燕敏; 李兰芳; 霍海如; 谭余庆

您当前的位置：

首页 >

文章列表页 >

4种活血化瘀中药有效成分对血管紧张素Ⅱ诱导的血管外膜成纤维细胞增殖及胶原合成的影响

更新时间：2024-01-04

- 4种活血化瘀中药有效成分对血管紧张素Ⅱ诱导的血管外膜成纤维细胞增殖及胶原合成的影响
- Effects of Four Active Components from Traditional Herbs on the Proliferation and Collagen Synthesis of Rat Vascular Adventitial Fibroblasts Induced by Angiotensin Ⅱ
- 中国实验方剂学杂志 2008年14卷第11期页码：68-70
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  中图分类号：
- 纸质出版日期：2008
- 稿件说明：
移动端阅览
鹿燕敏, 李兰芳, 霍海如, 等. 4种活血化瘀中药有效成分对血管紧张素Ⅱ诱导的血管外膜成纤维细胞增殖及胶原合成的影响[J]. 中国实验方剂学杂志, 2008,14(11):68-70.

LU Yan-min, LI Lan-fang, Huo Hai-ru, et al. Effects of Four Active Components from Traditional Herbs on the Proliferation and Collagen Synthesis of Rat Vascular Adventitial Fibroblasts Induced by Angiotensin Ⅱ[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(11): 68-70.
鹿燕敏, 李兰芳, 霍海如, 等. 4种活血化瘀中药有效成分对血管紧张素Ⅱ诱导的血管外膜成纤维细胞增殖及胶原合成的影响[J]. 中国实验方剂学杂志, 2008,14(11):68-70. DOI：

LU Yan-min, LI Lan-fang, Huo Hai-ru, et al. Effects of Four Active Components from Traditional Herbs on the Proliferation and Collagen Synthesis of Rat Vascular Adventitial Fibroblasts Induced by Angiotensin Ⅱ[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(11): 68-70. DOI：

摘要

目的:体外观察盐酸川芎嗪、葛根素、丹参酮ⅡA、丹皮酚对血管紧张素Ⅱ(ANG-Ⅱ)诱导的大鼠血管外膜成纤维细胞(VAF)的增殖及胶原蛋白合成的影响。方法:MTT法检测细胞增殖活性;羟脯氨酸比色法测定细胞培养上清液中胶原蛋白含量。结果:4种中药成分能够显著降低ANG-Ⅱ诱导的VAF增殖及细胞培养上清液中羟脯氨酸含量。结论:盐酸川芎嗪、葛根素、丹参酮ⅡA、丹皮酚能够抑制ANG-Ⅱ诱导的VAF增殖和胶原合成。

Abstract

Objective:The purpose of this study is to explore the effects of four active components from traditional herbs including tetramethylpyrazine

puerarin

tanshinone ⅡA and paeonol on the proliferation and collagen synthesis of vascular adventitial fibroblasts(VAF) induced by angiotensin Ⅱ(ANG-Ⅱ).Methods:MTT assay was used for observing cell proliferation

and hydroxyproline chromatometry was used for detecting collagen synthesis.Results:These four herbs significantly decreased the proliferation rate and the amount of hydroxyproline of VAF components from respectively.Conclusions:Tetramethylpyrazine

puerarin

tanshinone ⅡA and paeonol could decrease the proliferation and collagen synthesis of VAF.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

五劳七损方调控Wnt/β-catenin信号通路对AS成纤维细胞增殖及成骨分化的影响

马勃孢子粉醇提物对小鼠全层皮肤缺损性创面的治疗作用考察

大鼠血管外膜成纤维细胞的原代培养及生物学行为研究

补阳还五汤干预缺氧预适应成纤维细胞促间充质干细胞迁移的机制