Objective:To investigate Yiqi Yangyin Huoxue Recipe`s effect on serum PAI-1 level in insulin resistance(IR) rat induced by low dose of streptozotocin(STZ) and high calorie food to find out its functional target.Methods[WTBZ]:Male Wistar rats were randomly divided into normal group

model group

low dose of Yiqi Yangyin Huoxue Recipe treating group and high dose of Yiqi Yangyin Huoxue Recipe treating group.The rats of normal group were fed with common food while the others with high calorie food and injected with low dose of STZ.The weight

fasting blood glucose(FBG)

fasting insulin(FIns)

blood fat

PAI-1 level of all rats were measured

and insulin sensitivity index(ISI) was calculated accordingly.Results:Yiqi Yangyin Huoxue Recipe could reduce body weight of IR rats.According to the results of biochemical detection

Yiqi Yangyin Huoxue Recipe could reduce FBG level and FIns level

improve blood fat condition

enhance ISI while reduce serum PAI-1 level effectively(P<0.05).Conclusion:Yiqi Yangyin Huoxue Recipe can ameliorate IR condition of the model rat and its mechanism is probably related to the effect of reducing serum PAI-1 secretion.