化痰活血方拆方对高脂血症大鼠肝脏高密度脂蛋白受体基因表达的影响

闻莉1; 刘松林1; 叶勇2; 梅国强1

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化痰活血方拆方对高脂血症大鼠肝脏高密度脂蛋白受体基因表达的影响

更新时间：2024-01-04

- 化痰活血方拆方对高脂血症大鼠肝脏高密度脂蛋白受体基因表达的影响
- Influences of Divided Formula for Resolving Phlegm and Promoting Blood Circulation on the Expression of Scavenger Receptor,Class B Type Ⅰ(SR-BⅠ) in the Liver of the Hyperlipemia-modeled Rats
- 中国实验方剂学杂志 2007年13卷第7期页码：35-37
- 作者机构：
- 作者简介：
- 基金信息：
  
  湖北省自然科学基金项目(2005ABA126)、武汉市青年科技晨光计划项目(20055003059-35)、湖北中医学院2005年科研立项课题(2005-11)
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- 纸质出版日期：2007
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闻莉1, 刘松林1, 叶勇2, 等. 化痰活血方拆方对高脂血症大鼠肝脏高密度脂蛋白受体基因表达的影响[J]. 中国实验方剂学杂志, 2007,13(7):35-37.

WEN Li1, LIU Song-lin1, YE Yong2, et al. Influences of Divided Formula for Resolving Phlegm and Promoting Blood Circulation on the Expression of Scavenger Receptor,Class B Type Ⅰ(SR-BⅠ) in the Liver of the Hyperlipemia-modeled Rats[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(7): 35-37.
闻莉1, 刘松林1, 叶勇2, 等. 化痰活血方拆方对高脂血症大鼠肝脏高密度脂蛋白受体基因表达的影响[J]. 中国实验方剂学杂志, 2007,13(7):35-37. DOI：

WEN Li1, LIU Song-lin1, YE Yong2, et al. Influences of Divided Formula for Resolving Phlegm and Promoting Blood Circulation on the Expression of Scavenger Receptor,Class B Type Ⅰ(SR-BⅠ) in the Liver of the Hyperlipemia-modeled Rats[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(7): 35-37. DOI：

摘要

目的:拆方观察化痰活血方中化痰与活血药对高脂血症大鼠肝脏高密度脂蛋白受体(SR-BⅠ)基因表达的影响

从分子水平明确该方防治高脂血症的有效作用部位。方法:Wistar大鼠50只

随机分为空白组、模型组、全方组、化痰药组、活血药组

采用高脂饲料建立大鼠高脂血症模型。连续灌胃给药30d后

应用逆转录聚合酶链式反应(RT-PCR)法测定各组大鼠肝脏SR-BImRNA水平。结果:模型组大鼠肝SR-BImRNA表达明显低于空白组

化痰活血全方组和化痰药组大鼠肝SR-BImRNA水平明显高于模型组

而活血药组和模型组无明显差异

结论:化痰药是化痰活血方中促进高脂血症模型大鼠肝脏SR-BImRNA水平表达的主要组分

因而也是调节脂质代谢的主要作用部位。

Abstract

Objective:To observe the influences divided formula for resolving phlegm and promoting blood circulation on the expression of scavenger receptor

class B type Ⅰ(SR-BⅠ) in the liver of the hyperlipemia-modeled rats.Methods:50 Wistar rats were divided randomly into 5 groups:blank group

model group

full formula group

group of taking drugs for resolving phlegm

and group of taking drugs for promoting blood circulation.The model was established by high fat feeding into stomach daily except the blank group.After 30 days RT-PCR was adopted to messure the level of SR-BⅠ mRNA for each group.Results:The level of SR-BⅠ mRNA of model group was apparently lower than that of blank group.Compared to that of the model

SR-BⅠ mRNA of the full formula group and the group of taking drugs for resolving phlegm increased evidently

but there was no difference between model group and the group of taking drugs for promoting blood circulation for SR-BⅠ mRNA.Conclusion:In the full formula

the drugs for resolving phlegm play the most important role in elevating the level of SR-BⅠ mRNA in the liver of the hyperlipemia-modeled rats.

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