参附注射液对心衰大鼠血清内源性洋地黄样物质水平的影响

毛静远1; 魏广力2; 王恒和1; 李彬1; 葛永彬1; 王强1; 张运1; 李红1; 常延平1; 吴慧轩1; 王贤良3; 郭永铁1

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参附注射液对心衰大鼠血清内源性洋地黄样物质水平的影响

更新时间：2024-01-04

- 参附注射液对心衰大鼠血清内源性洋地黄样物质水平的影响
- Influence of Shenfu Injection on the Serum level of Endogenous Digoxin-Like Substance In Rats with Heart Failure
- 中国实验方剂学杂志 2007年13卷第7期页码：29-30
- 作者机构：
- 作者简介：
- 基金信息：
  
  天津市高等学校科技发展基金项目(20030111)
- DOI：
  中图分类号：
- 纸质出版日期：2007
- 稿件说明：
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毛静远1, 魏广力2, 王恒和1, 等. 参附注射液对心衰大鼠血清内源性洋地黄样物质水平的影响[J]. 中国实验方剂学杂志, 2007,13(7):29-30.

MAO Jing-yuan1, WEI Guang-li2, WANG Heng-he1, et al. Influence of Shenfu Injection on the Serum level of Endogenous Digoxin-Like Substance In Rats with Heart Failure[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(7): 29-30.
毛静远1, 魏广力2, 王恒和1, 等. 参附注射液对心衰大鼠血清内源性洋地黄样物质水平的影响[J]. 中国实验方剂学杂志, 2007,13(7):29-30. DOI：

MAO Jing-yuan1, WEI Guang-li2, WANG Heng-he1, et al. Influence of Shenfu Injection on the Serum level of Endogenous Digoxin-Like Substance In Rats with Heart Failure[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(7): 29-30. DOI：

摘要

目的:探讨不同剂量参附注射液(Shenfu Injection

SFI)对心力衰竭(Heart failure

HF)大鼠血清内源性洋地黄样物质(Endogenous digoxin-like substance

EDLS)水平的影响。方法:结扎大鼠左冠状动脉前降支致心肌梗死建立心力衰竭模型。将造模成功的HF大鼠24只随机分为对照组(生理盐水12ml/kg iv)和SFI低

中

高剂量组(SFI4

12ml/kg iv)

每组6只。用放射免疫(RIA)法测定不同时点大鼠血清EDLS浓度的变化。结果:SFI不同剂量均可提高HF大鼠血清EDLS的浓度

在给药即刻起效

这种影响至少维持8h

0.5h和4h时点2次出现峰值。结论:SFI可能具有刺激HF大鼠EDLS分泌和释放的作用。

Abstract

Objective:To evaluate the influence of Shenfu Injection(SFI) on the serum level of endogenous digoxin-like substance(EDLS) in rats with heart failure(HF).Methods:HF models were built up by ligating the left coronary artery of rats.Twenty-four model rats with HF were randomly divided into 4 groups:the control one(normal saline 12 ml/kg iv) and the low

middle and high dosage ones of SFI(normal saline plus SFI of 4 ml

8 ml

12 ml/kg iv respectively)

6 rats in each one.The serum levels of EDLS in the rats were examined by radioimmunoassay(RIA)before and after the medication.Results:Different dosage of SFI all showed the tendency of increasing the serum level of EDLS of the rats with HF.After the medication

the serum level of EDLS was risen at once

and maintained for 8 hours at least

the peak value appeared twice at 0.5 h and 4 h.Conclusion: SFI could increase the secretion and release of EDLS in the rats with HF.

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