LIU Bin, Qi Yun, SONG Yang, et al. Application of Modified Isobologram Method in Quantitative Analysis for the Interaction of Saponins of Fisch and A.DC[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(3): 40-42.
LIU Bin, Qi Yun, SONG Yang, et al. Application of Modified Isobologram Method in Quantitative Analysis for the Interaction of Saponins of Fisch and A.DC[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(3): 40-42.DOI:
Objective:To evaluate the expectorant and anti-inflammatory effects of the combinations of saponins of Glycyrrhiza uralensis Fisch(GS) and Platycodon grandiflorum A.DC(PS).Methods:The phenol drain model
xylene-induced mouse ear edema model and PLA2-induced mouse paw edema model were used
and the interaction between these two agents was evaluated by modified isobologram method.Result:With the decrease of total dose
the trend of interaction from antagonism to synergism was observed
and synergism or additivity was obtained at low effective doses.Conclusion:At fixed ratio
the total dose would affect the herbal interactive effects.