金草片对子宫肌瘤模型大鼠子宫组织一氧化氮合酶表达的影响

李建荣1; 2; 吴兰生1; 张广平1; 仝燕1; 王锦玉1

您当前的位置：

首页 >

文章列表页 >

金草片对子宫肌瘤模型大鼠子宫组织一氧化氮合酶表达的影响

更新时间：2024-01-04

- 金草片对子宫肌瘤模型大鼠子宫组织一氧化氮合酶表达的影响
- Effects of Jincao Tablet on Expression of Nitric Oxide Synthase in the Model of Uterine Leiomyoma in Rat
- 中国实验方剂学杂志 2007年13卷第5期页码：40-42
- 作者机构：
- 作者简介：
- 基金信息：
  
  科技部创新药物和中药现代化项目(2002AA2Z3225)
- DOI：
  中图分类号：
- 纸质出版日期：2007
- 稿件说明：
移动端阅览
李建荣1, 2, 吴兰生1, 等. 金草片对子宫肌瘤模型大鼠子宫组织一氧化氮合酶表达的影响[J]. 中国实验方剂学杂志, 2007,13(5):40-42.

LI Jian-rong1, 2, WU Lan-sheng1, et al. Effects of Jincao Tablet on Expression of Nitric Oxide Synthase in the Model of Uterine Leiomyoma in Rat[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(5): 40-42.
李建荣1, 2, 吴兰生1, 等. 金草片对子宫肌瘤模型大鼠子宫组织一氧化氮合酶表达的影响[J]. 中国实验方剂学杂志, 2007,13(5):40-42. DOI：

LI Jian-rong1, 2, WU Lan-sheng1, et al. Effects of Jincao Tablet on Expression of Nitric Oxide Synthase in the Model of Uterine Leiomyoma in Rat[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(5): 40-42. DOI：

摘要

目的:探讨金草片对子宫肌瘤模型大鼠子宫组织一氧化氮合酶(NOS)表达的影响

及该模型与临床发病机理的相关性。方法:以雌激素和雌、孕激素肌肉注射造成大鼠子宫肌瘤模型

测定子宫组织的总型NOS和诱导型NOS(iNOS)的水平;用放射配体结合分析法测定子宫组织雌激素受体(ER)水平;用放射免疫法测定血清雌二醇(E2)和孕酮(P)水平。结果:模型组大鼠子宫组织总型NOS和诱导型iNOS表达均明显增强

E2、ER和P水平升高;P水平与NOS表达相关

与iNOS表达不直接相关。金草片组可明显降低子宫组织NOSi、NOS和ER表达

降低血清E2和P水平

与模型组比较差异显著。结论:金草片可抑制子宫肌瘤模型大鼠子宫组织NOS表达

其作用可能是该品种治疗子宫肌瘤的作用机理之一。

Abstract

Objective:To investigate effects of Jincao tablet on expression of nitric oxide synthase in the model of uterine leiomyoma in rat and the relationship between the model and pathogenesis.Method:Rats were injected with diethyl stilbestrol and progesterone respectively.The expression of NOS and iNOS in uterine leiomyoma tissue were measured by kit;the levels of ER in uterine leiomyoma tissue was assayed by radioligand combination assay;the levels of E2 and P in serum was determined by radioimmunity.Result:Compared with normal group

the levels of and NOS

iNOS

E2 and P of model group were significantly decreased.The levels of P were related to NOS and were not related to iNOS.Jincao tablet group was obviously different from model group.Conclusion:Jincao tablet could improved the levels of immune function of the model of uterine leiomyoma in rat

and it might be played a role in the pathogenesis of leiomyoma.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

肌瘤清胶囊对子宫肌瘤模型大鼠血清NOS、TNF-α和IL-2水平的影响

桃红消癥散对子宫肌瘤模型大鼠雌、孕激素受体表达的影响

URWell对吗啡依赖小鼠戒断反应和NO/NOS系统的影响