阿胶对哮喘大鼠气道炎症及外周血Ⅰ型/Ⅱ型T辅助细胞因子的影响

赵福东; 董竞成; 崔焱; 谢瑾玉; 巫善美

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阿胶对哮喘大鼠气道炎症及外周血Ⅰ型/Ⅱ型T辅助细胞因子的影响

更新时间：2024-01-04

- 阿胶对哮喘大鼠气道炎症及外周血Ⅰ型/Ⅱ型T辅助细胞因子的影响
- The Effect of Ejiao on Airway Inflammation and Th1/Th2 Cytokines in Serum Of Asthmatic Rats
- 中国实验方剂学杂志 2006年12卷第6期页码：59-61
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- 纸质出版日期：2006
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赵福东, 董竞成, 崔焱, 等. 阿胶对哮喘大鼠气道炎症及外周血Ⅰ型/Ⅱ型T辅助细胞因子的影响[J]. 中国实验方剂学杂志, 2006,12(6):59-61.

ZHAO Fu-dong, DONG Jing-cheng, CUI Yan, et al. The Effect of Ejiao on Airway Inflammation and Th1/Th2 Cytokines in Serum Of Asthmatic Rats[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(6): 59-61.
赵福东, 董竞成, 崔焱, 等. 阿胶对哮喘大鼠气道炎症及外周血Ⅰ型/Ⅱ型T辅助细胞因子的影响[J]. 中国实验方剂学杂志, 2006,12(6):59-61. DOI：

ZHAO Fu-dong, DONG Jing-cheng, CUI Yan, et al. The Effect of Ejiao on Airway Inflammation and Th1/Th2 Cytokines in Serum Of Asthmatic Rats[J]. Chinese journal of experimental traditional medical formulae, 2006, 12(6): 59-61. DOI：

摘要

目的探讨阿胶对哮喘大鼠Th1/Th2细胞因子的影响及其防治哮喘的作用机制。方法60只Wistar大鼠随机分为生理盐水(NS)对照组(A)

低剂量阿胶组(B)

中剂量阿胶组(C)

高剂量阿胶组(D)

斯奇康组(E)

哮喘对照组(F)。用酶联免疫吸附试验(ELISA)检测血液中白介素-4(IL-4)、γ干扰素(IFN-γ)水平的变化。HE染色观察肺组织病理学变化。结果与NS对照组比较

哮喘模型组血液中IFN-γ水平显著降低(P<0.01)。与哮喘模型组比较

阿胶低、中剂量组和斯奇康组IL-4水平显著降低(P<0.01)

NS对照组、阿胶低、中剂量组和斯奇康组人鼠肺组织嗜酸性细胞浸润程度也明显减轻。结论哮喘大鼠存在Th2型细胞优势反应

而阿胶可能具有抑制哮喘Th2细胞优势反应的作用

从而调节Th1/Th2型细胞因子平衡

同时

可减轻哮喘大鼠肺组织嗜酸性细胞炎症反应。

Abstract

Objective:To study the effects of Ejiao on Th1/Th2 cytokines and the mechanism of which preventing and curing bronchial asthma.Methods:60 wistar rats were randomly divided into 6 groups.Group A was normal group which were administered with NS.Group B

C and D were administered with low

moderate and high dose Ejiao.Group E were administered with Polysaceharidc.Group F were asthma group.1L-4 and IFN-γ in serum were detected by enzyme-linked immunosorbent assay(ELISA).Results:Compared with normal group

the concentration of IFN-γ in group F was decreased significantly.compared with asthma group

the concentration of IL-4 of low and moderate dose Ejiao groups and Polysaceharidc group were decreased significantly(P<0.05)

and there was less eosinophils in the lungs of group A、B、C、E than that in group F.Conclusion:Ejiao could regulate the ratio of Th1/Th2 by decreasing Th2 subset instead of increasing Th1 subset.On the other hand

it could inhibit eosinophils to move from peripheral blood to the lungs of asthma rats.

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