固本化痰祛瘀汤治疗COPD缓解期的临床疗效及其对NO、ET的调节作用和意义

吴国珍; 刘红健; 高山凤

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固本化痰祛瘀汤治疗COPD缓解期的临床疗效及其对NO、ET的调节作用和意义

更新时间：2024-01-04

- 固本化痰祛瘀汤治疗COPD缓解期的临床疗效及其对NO、ET的调节作用和意义
- Effects of Guben Huatan Quyu Decoction on NO and ET in Patients with COPD during Remission Stage
- 中国实验方剂学杂志 2003年9卷第3期页码：40-42
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- 纸质出版日期：2003
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吴国珍, 刘红健, 高山凤. 固本化痰祛瘀汤治疗COPD缓解期的临床疗效及其对NO、ET的调节作用和意义[J]. 中国实验方剂学杂志, 2003,9(3):40-42.

WU Guo-zhen, LIU Hong-jian, GAO Shan-feng. Effects of Guben Huatan Quyu Decoction on NO and ET in Patients with COPD during Remission Stage[J]. Chinese journal of experimental traditional medical formulae, 2003, 9(3): 40-42.
吴国珍, 刘红健, 高山凤. 固本化痰祛瘀汤治疗COPD缓解期的临床疗效及其对NO、ET的调节作用和意义[J]. 中国实验方剂学杂志, 2003,9(3):40-42. DOI：

WU Guo-zhen, LIU Hong-jian, GAO Shan-feng. Effects of Guben Huatan Quyu Decoction on NO and ET in Patients with COPD during Remission Stage[J]. Chinese journal of experimental traditional medical formulae, 2003, 9(3): 40-42. DOI：

摘要

目的:探讨固本化痰祛瘀汤对COPD缓解期患者的治疗作用及其对血浆一氧化氮(NO)、内皮素(ET)水平的影响和意义。方法:将52例COPD缓解期患者随机分为治疗组及对照组

观察固本化痰祛瘀汤对COPD缓解期患者临床症状及血浆NO、ET水平的影响

并与单纯的补益固本汤对照组进行对比研究。结果:两组治疗后临床症状积分均显著下降

并且固本化痰祛瘀汤治疗组的证候积分改善程度明显优于对照组(P<0.05)。与治疗前比较

两组的血浆NO水平显著上升

ET水平显著下降(P<0.01或0.05)

而且治疗组ET水平下降幅度明显大于对照组(P<0.01)。

Abstract

Objective:To study the effects of Guben Huatan Quyu Decoction (GHQD) on the plasma levels of Nitric (NO) and Endothelin (ET)in patients with chronic obstructive pulmonary disease (COPD) during Remission Stage Method:Thirty-two COPD patients were treated with GHQD and 20 patients in control group were treated with Guben Decoction. The plasma levels of NO and ET were measured in all patients before and after treatment. And the clinical effects of the treatment were observed. Result: After treatment

the plasma level of NO increased (P<0.01) and the level of ET decreased (P<0.01 or P<0.05) significantly in both groups

moreover

the level of ET in patients treated with GHQD was significantly lower than in control group (P<0.01). And the curative effect in patients of GHQD group was much better than in control group.

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