金森脑泰注射剂中葛根素在生理及病理状态下大鼠肝肾分布的比较

王莉1; 邢东明1; 孙虹2; 金文2; 炎彬2; 杜力军1

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金森脑泰注射剂中葛根素在生理及病理状态下大鼠肝肾分布的比较

更新时间：2024-01-04

- 金森脑泰注射剂中葛根素在生理及病理状态下大鼠肝肾分布的比较
- Comparison of Puerarin of CBN Injection in the Liver and Kidney of Normal and Ischemia-reperfusion Rats
- 中国实验方剂学杂志 2002年8卷第3期页码：41-43
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家科技部95攻关项目:No96-901-05-105;清华大学基础研究基金No.JC2000061
- DOI：
  中图分类号：
- 纸质出版日期：2002
- 稿件说明：
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王莉1, 邢东明1, 孙虹2, 等. 金森脑泰注射剂中葛根素在生理及病理状态下大鼠肝肾分布的比较[J]. 中国实验方剂学杂志, 2002,8(3):41-43.

WANG Li2, XING Dong-ming1, SUN Hong2, et al. Comparison of Puerarin of CBN Injection in the Liver and Kidney of Normal and Ischemia-reperfusion Rats[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(3): 41-43.
王莉1, 邢东明1, 孙虹2, 等. 金森脑泰注射剂中葛根素在生理及病理状态下大鼠肝肾分布的比较[J]. 中国实验方剂学杂志, 2002,8(3):41-43. DOI：

WANG Li2, XING Dong-ming1, SUN Hong2, et al. Comparison of Puerarin of CBN Injection in the Liver and Kidney of Normal and Ischemia-reperfusion Rats[J]. Chinese journal of experimental traditional medical formulae, 2002, 8(3): 41-43. DOI：

摘要

目的:研究脑血管药金森脑泰注射剂(CBN)中葛根素在大鼠肝肾分布的药物动力学。方法:取正常和脑缺血再灌大鼠行股静脉给药。采血和肝肾。HPLC测定葛根素含量。计算肝肾中葛根素含量变化。结果:静脉给药后正常大鼠葛根素主要在肾脏分布。且分布较快。药后15min分布达峰值

30min迅速下降。肝脏分布量少

但达峰时间及分布特点同肾脏。缺血再灌大鼠肝脏药物浓度明显升高。为正常鼠的2倍强。肾脏达峰时间明显延迟为30min。结论:CBN中葛根素主要在肾脏分布。缺血再灌时经肾分布时间延迟。肝脏含量明显升高。生病理状态下肝肾二脏中葛根素存在着明显的药物动力学差异。

Abstract

To study puerarin in CBN injection on the active distribution in rat's liver and kidney

CBN injection was given (iv

100mg/kg)by femoral vein on both normal and cerebral ischemia reperfusion rats

then the blood by abdominal aorta and the liver and kidney were collected

and then puerarin from them was prepared. The concentration of prerarin from the samples was determined by HPLC and the active distribution of puerarin in both liver and kidney was determined at last. Results showed puerarin distributed quickly in liver and kidney after iv CBN injection in normal rats. The peak-time of concentration in kidney was at 15 min after injection

and downwards quickly at 30 min. In model rats

the concentration in liver was higher than normal rat 2 times as many as. The peak time was obviously delayed at 30 min after the injection. The results indicated the kidney was a major organ for puerarin distribution after CBN injection. But in model rats

the concentration of pueratinin kidney decreased

while increased in liver.

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