含药血清药理法观察扶正化瘀方抗肝纤维化的配伍作用

王晓玲1; 刘平2; 刘成海2; 刘成2; 顾宏图2

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含药血清药理法观察扶正化瘀方抗肝纤维化的配伍作用

更新时间：2024-01-04

- 含药血清药理法观察扶正化瘀方抗肝纤维化的配伍作用
- Investigation of Fuzheng Huayu Decoction on Coordination Effect of Anti-fibrosis of Liver with Serum Pharmacology
- 中国实验方剂学杂志 1999年5卷第6期页码：22-25
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家中医药管理局青年基金课题(97Y007)
- DOI：
  中图分类号：
- 纸质出版日期：1999
- 稿件说明：
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王晓玲1, 刘平2, 刘成海2, 等. 含药血清药理法观察扶正化瘀方抗肝纤维化的配伍作用[J]. 中国实验方剂学杂志, 1999,5(6):22-25.

WANG Xiao-ling1, LIU Ping2, LIU cheng-hai2, et al. Investigation of Fuzheng Huayu Decoction on Coordination Effect of Anti-fibrosis of Liver with Serum Pharmacology[J]. Chinese journal of experimental traditional medical formulae, 1999, 5(6): 22-25.
王晓玲1, 刘平2, 刘成海2, 等. 含药血清药理法观察扶正化瘀方抗肝纤维化的配伍作用[J]. 中国实验方剂学杂志, 1999,5(6):22-25. DOI：

WANG Xiao-ling1, LIU Ping2, LIU cheng-hai2, et al. Investigation of Fuzheng Huayu Decoction on Coordination Effect of Anti-fibrosis of Liver with Serum Pharmacology[J]. Chinese journal of experimental traditional medical formulae, 1999, 5(6): 22-25. DOI：

摘要

将扶正化瘀方分为扶正组、化瘀组、虫草组、丹参组及丹参加虫草组

灌胃给药分离药物血清

观察各药物血清对大鼠肝星状细胞增殖、活化、型胶原和TGFβ1蛋白及其mRNA表达的影响.各组药物血清均可抑制星状细胞的增殖和活化

其中化瘀组效果最明显;各组药物血清均可抑制星状细胞型胶原mRNA及其蛋白的生成

以扶正组效果最佳;各组药物血清星状细胞TGFβ1mRNA及其蛋白生成均有明显的降低

以虫草组作用最强.

Abstract

Fuzheng Huayu(FZHY) decoction was divided into five subgroups: Fuzheng group

Huayu group

Cordyceps group

Salvia Mitiorihizae group and Cordyceps plus Salvia Mitiorihizae group.Five types of serum containing correspondent drugs were collected from rats

respectively.The results showed that the five types of serum could inhibit hepatic stellate cells(HSC)and the effect of the serum containing Huayu was the best.The five types of serum could also inhibit mRNA expression and protein synthesis of type Ⅰ collagen in HSC

and the effect of the serum containing Fuzheng was the best.The five types of serum could also inhibit mRNA expression and protein synthesis of transforming growth factor β1 in HSC

and the effect of the serum containing Cordyceps was the best.

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