Objective: To study the anti-inflammatory

analgesic function and therapeutic effect on acute soft tissue injury of Shenjin Huoxue mixture(SJHXM). Method: ICR mice and SD rats were divided into 5 groups randomly including model control group

indomethacin group and SJHXM groups. SJHXM was given at dose of 6

18

54 g·kg-1 in mice and 2

6

18 g·kg-1 in rats for 7 days while indomethacin was 10

5 mg·kg-1

respectively. The anti-inflammatory effects of SJHXM were observed with the models of mouse ear swelling induced by xylene

rat paw swelling induced by carrageen

and mouse increasing peritoneal capillary permeability induced by acetic acid. Methods of acetic acid-induced writhing and hot-plate test in mice were used to study the analgesic effect. Models of acute soft tissue injury in rats caused by strike were established to observe the therapeutic effect of SJHXM. Result: Compared with the model group

SJHXM could significantly inhibit the ear swelling

lessen the paw swelling in rats

decrease the capillary permeability and the writhing times of mice

improve tissue repair ability

yet the pain threshold was almost unchanged. Conclusion: SJHXM showed anti-inflammatory

analgesic function and alleviated acute soft tissue injury to various degree.