Objective: To observe the effect of Buyang Huanwu decoction prescription on platelet activation and endothelial function in patients with diabetes and unstable angina. To evaluate the efficacy and possible mechanisms in patients with diabetes and unstable angina. Method: minty-two patients with type 2 diabetes mellitus(T2DM) and unstable angina pectoris(UAP) were randomLy divided into two groups: The control group (46 cases) was given conventional therapy; Chinese medicines group (46 cases) was given Buyang Huanwu decoction prescription on the basis of conventional treatment. These patients of two groups were treated for 30 days. Indicator of lysophosphatidic acid(LPA)

platelet α-granule membrane glycoprotein(CD62P)

glycopropean complex of activated platelets(PAC-1)

maximum platelet aggregation rate(MAR)

nitric oxide(NO)

endothelin-1(ET-1)

von Willebrand factor(vWF)

flow-mediated vasodilation(FMD)were observed before and after treatment. Result: Before the treatment

there were significant difference between the control group and the health group in these indicators of LPA

CD62P

PAC-1

MAR

NO

ET-1

vWF

FMD (all P<0.01)

there were no significant difference in these indicators between two groups(all P>0.05)

it has comparability. After 30 days

there indicators had significantly improved compared with before treatment in patients of two groups(P<0.05 or P<0.01)

But patients in Chinese medicines group improved more significantly(P<0.05 or P<0.01).Incidence of cardiovascular events TCM group was significantly lower than the control group within 30 days(P<0.05)

the difference was statistically significant.Application Chinese medicines group were no adverse reactions. Conclusion: It was safe and effective that Buyang Huanwu decoction prescription in the treatment of patients with T2DM and UAP

inhibition of platelet activation and protection of endothelial function may be one mechanism of the improvement prognosis of T2DM and UAP.